Toxicological profiles - Pyrethrins And Pyrethroids
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In this part, we look at how pyrethrins kill insects. Pyrethrins and pyrethroids are nerve poisons.
Even if they fail to produce tissue damage, their impact is sure to prove devastating. By binding to protein channels, they disturb the formation and further transmission of electrical signals action potentials; see Fig. Figure As nerve poisons, pyrethroids disturb the formation and further transmission of electrical signals. In the resting state, a potential difference exists between the two sides of the cell membrane: ca. Inside, the reverse is true. An external excitation of the neuron causes the sodium channels to open for ca.
This, in turn, causes the potential difference to fall depolarization; see Fig. The sodium channels then close, and the potassium channels simultaneously open. In the case of continuous excitation, the process repeats after a few milliseconds, causing the neuron to "fire" as often as times per second [69,70]. Treatment of an isolated frog neuron with allethrin 17 ; a synthetic pyrethroid results in multiple, uncontrolled action potentials see Fig.